I make manual saves now and then, and happen to have one about half an hour prior to the last autosave. Same result there, though, the game crashes while loading it. Very frustrating if that save is lost entirely, after spending hours on it and playing almost 20 years (I play at 2x).
Here are the mods I used. Don't think they should mess things up, but maybe you guys will know better. I've been away from the game for almost a year after all.
Betterfields (I had 3 small cropfields and a few pastures as the merchant dropped by with livestock)
Bobbi doctor house (not yet built a hospital)
College (not built)
Grain silo (not built)
Irrelevant tweak crops (3 cropfields, I started with pepper and pumpkin)
LongerLivingOrchards (my own, they live ~20 years)
Monastery (not built, do books actually do anything?)
MuteLivestock (active as I have some livestock now)
NoWind (my own, it simply turns off the annoying wind effect)
Rootcellar (I have built two root cellars)
Season2Year (changes a text field, hardly intrusive stuff)
Warehouse (not built)
Suppose I should back up the saves and try to reinstall and hope that goes better, considering loading earlier saves doesn't work either.
I really hope Luke hasn't abandoned this game, and that he'll eventually make a Linux (and Mac) version of the game. Last blog update almost 6 months ago
Tried to load a very old savegame, but with the same crashing result. After a few seconds, the guy 'mining' in the loading screen stops moving, and at that point everything has crashed, and there is an error message in the same workspace as the game is in ('behind' the game, in fullscreen). The game doesn't CTD, so I manually need to exit it.